ARCHIVAL REPORT Abnormal Hypothalamic Response to Light in Seasonal Affective Disorder
نویسندگان
چکیده
Background: Vulnerability to the reduction in natural light associated with fall/winter is generally accepted as the main trigger of seasonal affective disorder (SAD), whereas light therapy is a treatment of choice of the disorder. However, the relationship between exposure to light and mood regulation remains unclear. As compared with green light, blue light was shown to acutely modulate emotion brain processing in healthy individuals. Here, we investigated the impact of light on emotion brain processing in patients with SAD and healthy control subjects and its relationship with retinal light sensitivity.
منابع مشابه
Abnormal hypothalamic response to light in seasonal affective disorder.
BACKGROUND Vulnerability to the reduction in natural light associated with fall/winter is generally accepted as the main trigger of seasonal affective disorder (SAD), whereas light therapy is a treatment of choice of the disorder. However, the relationship between exposure to light and mood regulation remains unclear. As compared with green light, blue light was shown to acutely modulate emotio...
متن کاملGrowth hormone response to baclofen in patients with seasonal affective disorder: effects of light therapy.
There is evidence for gamma-aminobutyric acid (GABA) dysfunction in the pathophysiology and treatment response of patients with major depression, but this has not been studied in seasonal affective disorder (SAD). Growth hormone (GH) response to a challenge with a GABAB receptor agonist, baclofen, is considered an in vivo index of hypothalamic GABAB receptor function in humans. To explore the r...
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OBJECTIVE We reviewed previous studies that have described an association between abnormal functioning of the hypothalamic-pituitary-adrenal axis and depression. In addition to melancholic depression, a spectrum of conditions may be associated with increased and prolonged activation of the hypothalamic-pituitary-adrenal axis. In contrast another group of states is characterized by hypoactivatio...
متن کاملEpidemiology, etiology, and natural treatment of seasonal affective disorder.
There is much more seasonal difference in higher latitudes than in lower latitudes. In a significant portion of the population of the northern United States, the shorter days of fall and winter precipitate a syndrome that can consist of depression, fatigue, hypersomnolence, hyperphagia, carbohydrate craving, weight gain, and loss of libido. If these symptoms persist in the winter, abate as the ...
متن کاملEarly response to light therapy partially predicts long-term antidepressant effects in patients with seasonal affective disorder.
OBJECTIVE To determine if the antidepressant effect of 1 hour of light therapy is predictive of the response after 1 and 2 weeks of treatment in patients with seasonal affective disorder (SAD). PATIENTS Twelve patients with SAD. SETTING National Institutes of Health Clinical Center, Bethesda, Md. INTERVENTIONS Light therapy for 2 weeks. OUTCOME MEASURES Scores on the Seasonal Affective ...
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تاریخ انتشار 2011